Postnov Iu V, Reznikova M B, Boriskina G M
Biull Eksp Biol Med. 1975 Aug;80(8):39-42.
The activities of the Na+--K+-ATPase, succinic dehydrogenase (SDH/, lactic dehydrogenase (LDH/ and glucose-6-phosphat dehydrogenase (G-6-PDH/ were studied in the cortex outer and inner medulla of the kidneys of rats with spontaneous hypertension (SHR) and were compared with those of control normotensive Wistar rats. The SHR aged 6--8 weeks had durint the prehypertensive and the early hypertensive stage the same enzymatic activities as control rats. Rats with a steady SH aged 16-22 weeks had low specific activity of the, Na+--K+-ATPase, SDH and LDH in the outer medulla. The latter can be associated with decreased intensity of the energy metabolism and a reduction of the active sodium transport in the ascending limb of the loop of Henle in the SHR rats and cold cause the phenomenon of exaggerated natriuresis characteristic of hypertension.
研究了自发性高血压大鼠（SHR）肾脏皮质外层和内层髓质中钠钾ATP酶、琥珀酸脱氢酶（SDH）、乳酸脱氢酶（LDH）和葡萄糖-6-磷酸脱氢酶（G-6-PDH）的活性，并与对照正常血压的Wistar大鼠进行了比较。6-8周龄的SHR在高血压前期和早期高血压阶段的酶活性与对照大鼠相同。16-22周龄血压稳定的SHR大鼠外层髓质中钠钾ATP酶、SDH和LDH的比活性较低。后者可能与能量代谢强度降低以及SHR大鼠髓袢升支中活性钠转运减少有关，并可能导致高血压特有的钠利尿过度现象。
