[Na,K-ATPase from the outer kidney medulla of spontaneously hypertensive rats in ontogenesis].

Specific activity of Na,K-ATPase from kidney outer medulla microsomes of spontaneously hypertensive rats (SHR) and of normotensive Kyoto-Wistar rats (WKY) at different stages of ontogenesis was studied. A positive correlation was observed between the blood pressure level and specific Na,K-ATPase activity in SHR kidney medulla. At the malignant stage of the disease, the specific activity of Na,K-ATPase exceeded that of control by 67%. The inhibiting effect of blood serum from SHR on purified preparations of Na,K-ATPase was far more pronounced than that of WKY.