Hosseinzadeh Hossein, Sadati Nargess
Pharmaceutical Research Center, Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775-1365, Mashhad, I.R. Iran.
Phytother Res. 2003 Mar;17(3):279-81. doi: 10.1002/ptr.1114.
The antihypoxic activity of Allium sativum clove (garlic) aqueous and methanolic extracts was studied in mice. The extracts of garlic showed that the antihypoxic effect was dose-dependent. The minimum effective doses of aqueous and methanolic extracts were 0.2 g/kg and 5.12 g/kg, respectively. Phenytoin, 50 mg/kg, and R-phenylisopropyladenosine (R-PIA), 1.6 mg/kg (R-PIA) as positive controls increased survival time up to 52.5 +/- 2.9 min and 120.5 +/- 6 min, respectively, compared to normal saline (34.73 +/- 0.71 min). The high doses of aqueous (16.9 g/kg) and methanolic (12.8 g/kg) extracts increased survival time up to 73.17 +/- 4.9 and 68.41 +/- 3.7, respectively. These results indicated that the extracts of A. sativum cloves have a protective effect against hypoxia-induced lethality in mice.
研究了大蒜丁香的水提取物和甲醇提取物在小鼠体内的抗缺氧活性。大蒜提取物显示其抗缺氧作用具有剂量依赖性。水提取物和甲醇提取物的最小有效剂量分别为0.2 g/kg和5.12 g/kg。作为阳性对照的苯妥英（50 mg/kg）和R-苯异丙基腺苷（R-PIA，1.6 mg/kg）与生理盐水（34.73±0.71分钟）相比，分别将存活时间延长至52.5±2.9分钟和120.5±6分钟。高剂量的水提取物（16.9 g/kg）和甲醇提取物（12.8 g/kg）分别将存活时间延长至73.17±4.9和68.41±3.7。这些结果表明，大蒜丁香提取物对小鼠缺氧诱导的致死性具有保护作用。
