Hosseinzadeh Hossein, Nourbakhsh Mahnaz
Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, P O Box 91775-1365, and Center of Pharmaceutical Sciences Research, Mashhad, I.R.Iran.
Phytother Res. 2003 Sep;17(8):938-41. doi: 10.1002/ptr.1311.
The effect the aqueous and ethanol extracts of Rosmarinus officinalis L. aerial parts on morphine withdrawal syndrome was investigated in mice. The aqueous and ethanol extracts induced a significant antinociceptive activity in the writhing test. This activity was inhibited by naloxone pretreatment. Dependence was induced using subcutaneous injections of morphine daily for 3 days. On day 4, morphine was injected 2 h prior to the intraperitoneal injection of naloxone. The number of jumps during the 30 min period after naloxone injection was considered as a measure of the withdrawal syndrome. The results indicated that the aqueous (1.68 g/kg and 2.4 g/kg, i.p.) and ethanol (0.96 g/kg, i.p.) extracts reduced the number of jumps. Phytochemical study indicated that only the aqueous extract of R. officinalis has an alkaloid component. It is concluded that the aqueous and ethanol extracts of R. officinalis aerial parts could diminish morphine withdrawal syndrome.
研究了迷迭香叶部水提取物和乙醇提取物对小鼠吗啡戒断综合征的影响。在扭体试验中，水提取物和乙醇提取物均表现出显著的抗伤害感受活性。这种活性可被纳洛酮预处理抑制。通过每天皮下注射吗啡连续3天诱导产生依赖性。在第4天，于腹腔注射纳洛酮前2小时注射吗啡。将纳洛酮注射后30分钟内的跳跃次数作为戒断综合征的衡量指标。结果表明，水提取物（腹腔注射，剂量分别为1.68 g/kg和2.4 g/kg）和乙醇提取物（腹腔注射，剂量为0.96 g/kg）可减少跳跃次数。植物化学研究表明，只有迷迭香水提取物含有生物碱成分。得出结论，迷迭香叶部水提取物和乙醇提取物可减轻吗啡戒断综合征。
