Hays Nicholas P, Bathalon Gaston P, Meydani Simin N, Leka Lynette S, Lipman Ruth, Roubenoff Ronenn, Schaefer Ernst J, Roberts Susan B
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA.
Aging Clin Exp Res. 2002 Dec;14(6):465-73. doi: 10.1007/BF03327346.
The extent to which general characteristics of metabolic aging contribute to differences in life span among individuals remains uncertain. The objective of this study was to examine the association of age-related physiological and metabolic variables with predicted longevity in postmenopausal women.
Subjects were 33 healthy women aged 55-65 years. Total and resting energy expenditure, body temperature, immune function as assessed by a delayed-type hypersensitivity skin test (DTH), lipid profile, and reported dietary intake were measured.
There were no significant associations between longevity, energy expenditure, body temperature, lipid profile, or dietary intake. However, there was a significant association of predicted longevity with DTH (partial r=0.44, p=0.023).
These results suggest that immune function may predict familial differences in longevity, while energy expenditure, body temperature, lipid profile, and dietary intake are unrelated. Although the small sample size may have limited the ability to detect metabolic effects on longevity in this study, the general approach may be broadly applicable to examinations of metabolic aging in humans.
代谢衰老的一般特征在多大程度上导致个体寿命差异仍不确定。本研究的目的是检验绝经后女性中与年龄相关的生理和代谢变量与预测寿命之间的关联。
研究对象为33名年龄在55 - 65岁的健康女性。测量了总能量消耗和静息能量消耗、体温、通过迟发型超敏皮肤试验（DTH）评估的免疫功能、血脂谱以及报告的饮食摄入量。
寿命、能量消耗、体温、血脂谱或饮食摄入量之间无显著关联。然而，预测寿命与DTH存在显著关联（偏相关系数r = 0.44，p = 0.023）。
这些结果表明免疫功能可能预测寿命的家族差异，而能量消耗、体温、血脂谱和饮食摄入量与之无关。尽管本研究中样本量较小可能限制了检测代谢对寿命影响的能力，但该一般方法可能广泛适用于人类代谢衰老的研究。
