Guardigli A, Lefar M S, Gallo M A
Arch Environ Contam Toxicol. 1976;4(2):145-54. doi: 10.1007/BF02221019.
The herbicide oxadiazon, 2-(tert-butyl)-4-(2,4-dichloro-5-isopropyloxy-phenyl)-delta 2-1,3,4-oxadiazoline 5-one, was fed in a total diet at three dosage levels to groups of dairy cows (0.5, 2.5, and 25 ppm) and to groups of male and laying female quail (20, 80, and 160 ppm) for 28 days. Control animals received basal diet rations. No residue (less than 5 ppb) was detected in milk or cream after three days withdrawal from fortified feed. The maximum plateau reached in milk was 83.8 ppb at the highest dosage fed. Tissues of cows sacrificed on the 12th day of withdrawal showed no residue (less than 20 ppb). Birds were sacrified at weekly intervals during acclimation, intake, and withdrawal periods. Eggs were collected at the same intervals. Tissues were free of oxadiazon residue (less than 40 ppb) within two to seven days of returning the quail to the basal ration, and the eggs were residue-free within seven to fourteen days. The maximum residue found in adipose tissue of quail and their fresh eggs was 3100 ppb and 5400 ppb, respectively at the greatly exaggerated dosage of 160 ppm in the diet. A comprehensive analytical methodology, including liquid-liquid partition, absorption chromatography and electron-capture gas chromatography will be discussed.
除草剂恶草酮，即2-（叔丁基）-4-（2,4-二氯-5-异丙氧基苯基）-Δ2-1,3,4-恶二唑啉-5-酮，以三种剂量水平添加到全价日粮中，分别喂给几组奶牛（0.5、2.5和25 ppm）以及几组雄性和产蛋雌性鹌鹑（20、80和160 ppm），持续28天。对照动物接受基础日粮。从强化饲料中撤出三天后，在牛奶或奶油中未检测到残留（低于5 ppb）。在喂食的最高剂量下，牛奶中达到的最大平台期为83.8 ppb。在撤药第12天宰杀的奶牛组织未显示残留（低于20 ppb）。在适应期、摄入期和撤药期，每周对鸟类进行宰杀。以相同的时间间隔收集鸡蛋。在鹌鹑恢复基础日粮后的两到七天内，组织中没有恶草酮残留（低于40 ppb），鸡蛋在七到十四天内无残留。在日粮中160 ppm这种极大夸张的剂量下，鹌鹑脂肪组织及其新鲜鸡蛋中发现的最大残留分别为3100 ppb和5400 ppb。将讨论一种综合分析方法，包括液-液分配、吸附色谱法和电子捕获气相色谱法。
