Calandra-Buonaura Giovanna, Basso Gianpaolo, Gorno-Tempini Maria Luisa, Serafini Marco, Pagnoni Giuseppe, Baraldi Patrizia, Porro Carlo Alberto, Nichelli Paolo
Department of Neurosciences, University of Modena and Reggio Emilia, Italy.
Funct Neurol. 2002 Oct-Dec;17(4):183-91.
The purpose of this study was to validate a functional magnetic resonance imaging (fMRI) paradigm to activate both anterior and posterior language areas while collecting accuracy and reaction time data on subjects' performance. The paradigm was based on alternating graphemic and lexical decision tasks. In line with the classical model of language organisation, based on lesion data, and with the results of previous neuroimaging studies, cortical activation associated with lexical decision-making was strongly lateralised to the left hemisphere and involved a network of regions in the frontal, temporal and parietal lobes. Single subject analysis demonstrated that the activation paradigm we propose is suitable for detecting language processing areas in humans for clinical studies.
本研究的目的是验证一种功能磁共振成像（fMRI）范式，该范式在收集受试者表现的准确性和反应时间数据时，能同时激活前语言区和后语言区。该范式基于交替的字形和词汇判断任务。根据基于病变数据的经典语言组织模型以及先前神经影像学研究的结果，与词汇判断相关的皮层激活强烈偏向左侧半球，并涉及额叶、颞叶和顶叶的一系列区域。单受试者分析表明，我们提出的激活范式适用于在临床研究中检测人类的语言处理区域。
