Stearns Stephen C, Magwene Paul
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520-8106, USA.
Am Nat. 2003 Feb;161(2):171-80. doi: 10.1086/367983.
Functional genomics provides new opportunities to address issues of fundamental interest in evolutionary biology and suggests many new research directions that are ripe for evolutionary investigation. New types of data, and the ability to study biological processes from a whole genome perspective, are likely to have a profound impact on evolutionary biology and ecology. To illustrate, we discuss how genomewide gene expression studies can be used to reformulate questions about trade-offs and pleiotropy. We then touch on some of the new research opportunities that the application of functional genomics affords to evolutionary biologists. We end with some brief notes about how evolutionary biology and comparative approaches will probably have an impact on functional genomics.
功能基因组学为解决进化生物学中具有根本重要性的问题提供了新机会，并提出了许多适合进行进化研究的新方向。新型数据以及从全基因组角度研究生物过程的能力，可能会对进化生物学和生态学产生深远影响。为了加以说明，我们讨论了全基因组基因表达研究如何能够用于重新阐述有关权衡和多效性的问题。接着，我们探讨了功能基因组学的应用为进化生物学家带来的一些新研究机会。最后，我们简要提及进化生物学和比较方法可能会对功能基因组学产生何种影响。
