Clarenbach P, Raffel G, Meyer D K, Hertting G
Arch Int Pharmacodyn Ther. 1976 Jan;219(1):79-86.
Niflumic acid and indomethacin showed to be inhibitors of catecholamine--uptake into rat striatal and hypothalamic synaptosomes. Whereas the inhibition by niflumic acid was non-competitive for both amines at similar Ki values, the action of indomethacin displayed differences between areas as well as amines: the potency of inhibition by indomethacin was greater in striatal than in hypothalamic synaptosomes irrespective of the amine; the type of inhibition by indomethacin was non-competitive for norepinephrine, but competitive for dopamine regardless of the brain area.
尼氟酸和吲哚美辛被证明是儿茶酚胺摄取到大鼠纹状体和下丘脑突触体中的抑制剂。虽然尼氟酸对两种胺的抑制作用在相似的Ki值下是非竞争性的，但吲哚美辛的作用在不同脑区以及不同胺之间表现出差异：无论胺的种类如何，吲哚美辛在纹状体突触体中的抑制效力都比在下丘脑突触体中更强；吲哚美辛对去甲肾上腺素的抑制类型是非竞争性的，但对多巴胺的抑制类型无论在哪个脑区都是竞争性的。
