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二丁酰环磷腺苷、茶碱和罂粟碱对大鼠脑纹状体和皮质突触体释放3H-儿茶酚胺的影响。

The effects of dibutyryl cyclic AMP, theophylline and papaverine on the release of 3H-catecholamines from rat brain striatal and cortical synaptosomes.

作者信息

Eitan A, Hershkowitz M

出版信息

Eur J Pharmacol. 1977 Dec 15;46(4):323-7. doi: 10.1016/0014-2999(77)90226-6.

DOI:10.1016/0014-2999(77)90226-6
PMID:201472
Abstract

Papaverine enhances the spontaneous release of 3H-dopamine from rat brain striatal synaptosomes and 3H-noradrenaline from cortical synaptosomes in a dose-dependent way. Neither dibutyryl cyclic AMP nor theophylline had any significant effect on either spontaneous or on potassium-evoked 3H-catecholamine release. It is suggested that the effect of papaverine on catecholamine release is not due to its phosphodiesterase inhibitory potency.

摘要

罂粟碱能以剂量依赖的方式增强大鼠脑纹状体突触体中3H-多巴胺以及皮质突触体中3H-去甲肾上腺素的自发释放。二丁酰环磷酸腺苷和茶碱对自发的或钾诱发的3H-儿茶酚胺释放均无显著影响。提示罂粟碱对儿茶酚胺释放的作用并非因其磷酸二酯酶抑制能力。

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引用本文的文献

1
Forskolin and the release of noradrenaline in cerebrocortical slices.福斯高林与大脑皮质切片中去甲肾上腺素的释放
Naunyn Schmiedebergs Arch Pharmacol. 1984 Jan;325(1):17-24. doi: 10.1007/BF00507049.
2
Catecholamine metabolism in rat brain following the intracerebroventricular administration of cyclic nucleotides.脑室内注射环核苷酸后大鼠脑内的儿茶酚胺代谢
J Neural Transm. 1982;55(1):1-8. doi: 10.1007/BF01243336.
3
Papaverine stimulation of prostaglandin E2 production by cultured rabbit gastric mucosa.罂粟碱对培养的兔胃黏膜前列腺素E2生成的刺激作用。
Gut. 1979 Oct;20(10):882-5. doi: 10.1136/gut.20.10.882.