Messiha F S
Arch Int Pharmacodyn Ther. 1976 Jan;219(1):87-96.
A pharmacokinetic study of the distribution and retention profiles of Li+, Rb+ and Cs+ in the brain and blood was performed in male mice given single (acute) or repeated (semi-chronic) injections of the respective chloride salt solutions. The concentration of Li+ in whole brain and in cerebral cortex, striatum, hippocampus, diencephalon, brain stem and cerebellum were similar after acute and semichronic LiCl treatment. In contrast, semi-chronic RbCl and CsCl treatment resulted in greater accumulation of Rb+ and Cs+ in brain compared to the levels obtained after acute administration. The Li+ concentration in brain declined to negligible amounts at 48 hr after termination of acute or semi-chronic LiCl administration, while the Rb+ and Cs+ concentration in the brain remained elevated for up to 6 days after termination of semi-chronic treatment. Differences in the distribution and retention patterns of Li+, Rb+ and Cs+ also were observed in the brain regions examined. In the blood, the concentration of Li+ reached a peak soon after LiCl administration and then progressively declined while Rb+ and Cs+ concentrations showed a biphasic course with the highest levels obtained 48 hr after administration of the salt solutions. It is suggested that the differences observed in the pharmacokinetics of Li+ compared to Rb+ and Cs+ in the brain might be related to their duration of actions.
对雄性小鼠单次（急性）或重复（半慢性）注射相应的氯化物盐溶液后，进行了Li⁺、Rb⁺和Cs⁺在脑和血液中的分布及滞留情况的药代动力学研究。急性和半慢性LiCl处理后，全脑以及大脑皮层、纹状体、海马体、间脑、脑干和小脑中Li⁺的浓度相似。相比之下，与急性给药后获得的水平相比，半慢性RbCl和CsCl处理导致脑中Rb⁺和Cs⁺的蓄积更多。急性或半慢性LiCl给药终止后48小时，脑中Li⁺浓度降至可忽略不计的水平，而半慢性处理终止后长达6天，脑中Rb⁺和Cs⁺浓度仍保持升高。在所检查的脑区中也观察到Li⁺、Rb⁺和Cs⁺分布和滞留模式的差异。在血液中，LiCl给药后Li⁺浓度很快达到峰值，然后逐渐下降，而Rb⁺和Cs⁺浓度呈现双相过程，在盐溶液给药后48小时达到最高水平。有人认为，脑中Li⁺与Rb⁺和Cs⁺药代动力学方面观察到的差异可能与其作用持续时间有关。
