Messiha F S
Pharmacol Biochem Behav. 1984;21 Suppl 1:87-92. doi: 10.1016/0091-3057(84)90169-2.
The distribution of exogenously administered Li+, Rb+ and Cs+ in distinct mouse brain regions was studied as a function of time subsequent termination of a short-term daily treatment with these alkali metal salts. The resulting distribution profiles were compared with that obtained from the corresponding endogenous alkali metals. Endogenous Rb+ and Cs+ were readily measurable in all 6 brain regions studied compared to traces of measurable Li+. The Rb+ concentration was greater than that of Cs+. Short-term treatment with equal doses of the alkali metals studied showed greater brain accumulation of Rb+ and Cs+ than Li+ with a prolonged brain regions preference for Cs+ storages as a function of time. Duration of ethanol-mediated narcosis was reduced from saline controls by pretreatment with RbCl or CsCl as contrasted with prolongation by LiCl. The narcotic dosage of ethanol used reduced endogeneous Li+ and increased Cs+ levels in the cerebellum. This massive ethanol dosage exerted little effect on the distribution of exogenously administered Cs+ with exception of the striatum which continued to show a high content of Cs+. This may have contributed to partial antagonism of ethanol-depressant action and to restoring of motor function, i.e., rapid regaining of righting reflex. The results showed that Cs+ possessed longer biological life time in the brain than Rb+ or Li+ which may be of therapeutic value, i.e., in the use of Cs salts in treatment of brain tumors and in conjunction with psychoactive agents provided the respective chemotherapeutic and antidepressant properties of CsCl have been established.
研究了外源性给予的Li⁺、Rb⁺和Cs⁺在不同小鼠脑区的分布情况，作为短期每日用这些碱金属盐治疗结束后时间的函数。将所得分布曲线与相应内源性碱金属的分布曲线进行比较。与可测量的痕量Li⁺相比，在所研究的所有6个脑区中，内源性Rb⁺和Cs⁺易于测量。Rb⁺浓度高于Cs⁺。用等剂量的所研究碱金属进行短期治疗显示，Rb⁺和Cs⁺在脑中的积累比Li⁺更多，并且随着时间的推移，脑区对Cs⁺储存的偏好延长。与LiCl导致的延长相反，用RbCl或CsCl预处理可使乙醇介导的麻醉持续时间比生理盐水对照组缩短。所用乙醇的麻醉剂量降低了小脑内源性Li⁺水平并增加了Cs⁺水平。除纹状体继续显示高含量的Cs⁺外，这种大量乙醇剂量对外源性给予的Cs⁺分布几乎没有影响。这可能有助于部分拮抗乙醇的抑制作用并恢复运动功能，即快速恢复翻正反射。结果表明，Cs⁺在脑中的生物半衰期比Rb⁺或Li⁺长，这可能具有治疗价值，即如果已确定CsCl具有相应的化疗和抗抑郁特性，则可将其用于治疗脑肿瘤以及与精神活性药物联合使用。
