Lau Dana, Flannery John
School of Optometry and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.
Doc Ophthalmol. 2003 Jan;106(1):89-98. doi: 10.1023/a:1022481306146.
These experiments evaluate overexpression of basic fibroblast growth factor (FGF-2) as a treatment to decrease photoreceptor cell death in the constant light damage model of retinal degeneration. Increased FGF-2 expression was accomplished by gene transfer to the retina via injection into the subretinal space of a recombinant adeno-associated virus (rAAV), containing the FGF-2 gene. Rescue effects were assessed by morphometry and electroretinographic analysis.
这些实验评估了碱性成纤维细胞生长因子（FGF-2）过表达作为一种治疗方法，以减少视网膜变性持续光照损伤模型中光感受器细胞的死亡。通过将含有FGF-2基因的重组腺相关病毒（rAAV）注射到视网膜下间隙，将基因转移到视网膜来实现FGF-2表达的增加。通过形态学测量和视网膜电图分析评估挽救效果。
