González-Sáiz José M, Pizarro Consuelo, Garrido-Vidal Diego
Chemical Engineering and Analytical Chemistry, Department of Chemistry, University of La Rioja, C/Madre de Dios 51, 26006 Logroño, La Rioja, Spain.
Biotechnol Prog. 2003 Mar-Apr;19(2):599-611. doi: 10.1021/bp0256871.
The most important kinetic models developed for acetic fermentation were evaluated to study their ability to explain the behavior of the industrial process of acetification. Each model was introduced into a simulation environment capable of replicating the conditions of the industrial plant. In this paper, it is proven that these models are not suitable to predict the evolution of the industrial fermentation by the comparison of the simulation results with an average sequence calculated from the industrial data. Therefore, a new kinetic model for the industrial acetic fermentation was developed. The kinetic parameters of the model were optimized by a specifically designed genetic algorithm. Only the representative sequence of industrial concentrations of acetic acid was required. The main novelty of the algorithm is the four-composed desirability function that works properly as the response to maximize. The new model developed is capable of explaining the behavior of the industrial process. The predictive ability of the model has been compared with that of the other models studied.
为研究醋酸发酵所开发的最重要的动力学模型,对其解释醋酸工业生产过程行为的能力进行了评估。每个模型都被引入到一个能够复制工厂条件的模拟环境中。通过将模拟结果与根据工业数据计算出的平均序列进行比较,本文证明这些模型不适用于预测工业发酵的进程。因此,开发了一种新的工业醋酸发酵动力学模型。该模型的动力学参数通过专门设计的遗传算法进行了优化。只需要醋酸工业浓度的代表性序列。该算法的主要新颖之处在于四部分组成的合意性函数,它作为要最大化的响应能正常工作。所开发的新模型能够解释工业过程的行为。已将该模型的预测能力与所研究的其他模型的预测能力进行了比较。