Notch与癌症：最好避免起伏。

Notch and cancer: best to avoid the ups and downs.

作者信息

Maillard Ivan, Pear Warren S

机构信息

Division of Hematology-Oncology, Institute for Medicine and Engineering, University of Pennsylvania, 611 BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

出版信息

Cancer Cell. 2003 Mar;3(3):203-5. doi: 10.1016/s1535-6108(03)00052-7.

DOI:10.1016/s1535-6108(03)00052-7

PMID:12676578

Abstract

The Notch pathway is known for its multiple important roles in development and tissue homeostasis, and it can be subverted during oncogenic transformation. Two recent studies add to our understanding of Notch in cancer biology in contrasting ways, by showing novel mechanisms of Notch pathway activation in cancer cells, and by indicating that in some circumstances, Notch can behave as a tumor suppressor.

摘要

Notch信号通路以其在发育和组织稳态中的多种重要作用而闻名，并且在致癌转化过程中可能被颠覆。最近的两项研究以截然不同的方式增进了我们对Notch在癌症生物学中作用的理解，一项研究揭示了癌细胞中Notch信号通路激活的新机制，另一项则表明在某些情况下，Notch可起到肿瘤抑制因子的作用。