Notch在癌症中的多种作用：背景决定一切。

Multiple niches for Notch in cancer: context is everything.

作者信息

Weng Andrew P, Aster Jon C

机构信息

Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

出版信息

Curr Opin Genet Dev. 2004 Feb;14(1):48-54. doi: 10.1016/j.gde.2003.11.004.

DOI:10.1016/j.gde.2003.11.004

PMID:15108805

Abstract

Notch receptor signaling has very distinctive roles in cancers originating from different types of cells that reflect its complex functions in normal tissue development and homeostasis. For example, recent studies have shown that Notch signals are oncogenic in pre-T cells but suppress tumor development in keratinocytes. Notch signaling contributes to pre-malignant metaplastic changes that precede pancreatic carcinoma, and it is also likely to be involved in other forms of metaplasia. In addition, several viral oncoproteins and chromosomal translocations target one or more components of a Notch transcriptional activation complex.

摘要

Notch受体信号传导在源自不同类型细胞的癌症中具有非常独特的作用，这反映了其在正常组织发育和内环境稳定中的复杂功能。例如，最近的研究表明，Notch信号在pre-T细胞中具有致癌性，但在角质形成细胞中抑制肿瘤发展。Notch信号传导促成了胰腺癌之前的癌前化生变化，并且也可能参与其他形式的化生。此外，几种病毒癌蛋白和染色体易位靶向Notch转录激活复合体的一个或多个组分。