Bizzarri Federico, Mondillo Sergio, Guerrini Francesco, Barbati Riccardo, Frati Giacomo, Davoli Giuseppe
Istituto di Chirurgia Toracica, Cardiovascolare e Tecnologie Biomediche, Università degli Studi di Siena, Siena, Italy.
Can J Cardiol. 2003 Mar 15;19(3):297-9.
Spontaneous coronary artery dissection is an unusual trigger for acute coronary syndrome or sudden death, occurring more frequently in relatively young people and mainly in the female sex. The underlying mechanism is not completely understood, but predisposing factors may include metabolism and collagen synthesis disorders. The case of a 34-year-old woman who underwent coronary angiography for acute anterolateral myocardial ischemia after cocaine abuse is reported. Dissection of the left main trunk extending to both proximal descending anterior and circumflex arteries was detected and the patient was promptly and successfully managed with tirofiban hydrochloride infusion and urgent coronary artery bypass grafting.
自发性冠状动脉夹层是急性冠状动脉综合征或猝死的一种不常见诱因，在相对年轻的人群中更常见，且主要发生于女性。其潜在机制尚未完全明确，但易感因素可能包括代谢和胶原蛋白合成紊乱。本文报道了一名34岁女性的病例，该女性在滥用可卡因后因急性前侧壁心肌缺血接受了冠状动脉造影。检查发现左主干夹层延伸至近端前降支和回旋支动脉，通过静脉输注盐酸替罗非班和紧急冠状动脉旁路移植术，患者得到了及时且成功的治疗。
