Chambon Y, Huet J, Le Calve M, Picard F
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Norethisterone samples are often contaminated by estrogen traces which can be measured by mass spectrometry and which invest the progestative with estrogenic properties in the Allen and Doisy test. Therefore, one had better, in pharmacodynamic experimenting, use samples that have been purified by chromatography or that are pure out of synthesis. However, one will not forget these are not without some estrogenicity, a fact which seems linked to the very nature of the norethisterone molecule.
炔诺酮样品常常被雌激素痕量所污染，这些痕量雌激素可以通过质谱法进行测量，并且在艾伦和多伊西试验中使孕激素具有雌激素特性。因此，在药效学实验中，最好使用经过色谱法纯化或合成出来就是纯品的样品。然而，不要忘记这些样品并非完全没有雌激素活性，这一事实似乎与炔诺酮分子的本质有关。
