Chambon Y, Picard F, Le Calvé M
C R Seances Soc Biol Fil. 1977;171(3):631-5.
We have shown, through a test proceeding from the McPhail test, in the immature rabbit female, the existence of succession and simultaneity synergisms between ethynylestradiol and pure or impure norethisterone, given by oral route. The estrogen, administrated before the progestative, is able to potentialize the action of the latter on the building of the endometrial lace in 5 days, more than on the lengthening of it in 15 days. Ethynylestradiol, absorbed with norethisterone, strengthens the effects of the latter on the second phenomenon more than on the first one. Absolute and relative doses of the estrogen and of the progestative differ only lightly according as norethisterone is pure or not pure, because of the more potent estrogenicity of the impure norethisterone.
我们通过一项源自麦克费尔试验的测试，在未成熟雌性家兔身上，证实了口服乙炔雌二醇与纯或不纯炔诺酮之间存在相继协同作用和同时协同作用。在孕激素之前给予雌激素，能够使后者对子宫内膜皱襞形成的作用在5天内增强，而不是在15天内对其延长的作用增强。与炔诺酮一同吸收的乙炔雌二醇，对后者第二种现象的作用增强程度大于对第一种现象的作用增强程度。由于不纯炔诺酮具有更强的雌激素活性，雌激素和孕激素的绝对剂量和相对剂量仅因炔诺酮是否纯净而略有不同。
