Freye E
Basic Res Cardiol. 1976 Mar-Apr;71(2):192-8. doi: 10.1007/BF01927871.
The purpose of this study was to determine the reactions of the cardiovascular system with special reference to myocardial oxygen consumption (MVO2) after the administration of graded doses (up to 2.4 g/kg) of thiamine. The data obtained indicate that thiamine: 1. Decreases mean peripheral pressure up to 25%. 2. Decreases LVEDP, left ventricular pressure, and LV dP/dtmax up to 10%, 15%, and 20% respectively. 3. Reduces pulse rate up to 25%. 4. Reduces coronary sinus blood flow up to 31%. 5. Reduces myocardial oxygen consumption up to 45%. The reduction in LVEDP, LVP, and LV dP/dtmax could be antagonized by dextran or norepinephrine infusion. It is suggested that thiamine blocks alpha-receptors which leads to pooling of blood with a concomitant reduction in pre- and afterload of the heart. The effect on MVO2 suggests that thiamine, the essential coenzyme for the formation of high energy substrates reduced the metabolic needs of the heart. The drug warrants further investigation for the treatment of myocardial ischemia.
本研究的目的是确定在给予分级剂量（高达2.4 g/kg）的硫胺素后，心血管系统的反应，特别关注心肌耗氧量（MVO2）。获得的数据表明，硫胺素：1. 使平均外周压降低达25%。2. 使左心室舒张末期压力（LVEDP）、左心室压力和左心室dp/dtmax分别降低达10%、15%和20%。3. 使脉搏率降低达25%。4. 使冠状窦血流量降低达31%。5. 使心肌耗氧量降低达45%。LVEDP、左心室压力（LVP）和左心室dp/dtmax的降低可被右旋糖酐或去甲肾上腺素输注所拮抗。提示硫胺素阻断α受体，导致血液淤积，同时心脏的前负荷和后负荷降低。对MVO2的影响表明，硫胺素作为形成高能底物的必需辅酶，降低了心脏的代谢需求。该药物在治疗心肌缺血方面值得进一步研究。
