蝙蝠葛酚性碱对麻醉犬血流动力学及冠脉循环的影响
[Effects of phenolic alkaloids of Menispermum dauricum on the hemodynamics and coronary circulation in anesthetized dog].
作者信息
Li Ying-qian, Yang Xiao-yan, Zhou Shun-chang, Gong Pei-li
机构信息
Institute of Clinical Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
出版信息
Yao Xue Xue Bao. 2003 Sep;38(9):658-60.
AIM
To observe the effect of phenolic alkaloids of Menispermum dauricum (PAMD) on the hemodynamics, coronary circulation and oxygen metabolism of the myocardium in anesthetized dogs.
METHODS
In this study, the changes of LVSP, LVEDP and +/- dp/dtmax, the flow of coronary artery and myocardial energy metabolism were measured in anesthetized dog with PAMD or NS.
RESULTS
In the anesthetized dogs, compared with pre-treatment status, PAMD at 3.5 and 7.0 mg.kg-1 caused decreases in the left ventricular systolic pressure(LVSP), +/- dp/dtmax, heart rate, the rate of oxygen utilization, the coronary and general peripheral resistance. It was found to increase myocardial oxygen and coronary flow. There were no significant change in the left ventricular end diastolic pressure (LVEDP).
CONCLUSION
PAMD can ameliorate hemodynamics, coronary circulation and myocardial metabolism.
目的
观察蝙蝠葛酚性碱（PAMD）对麻醉犬血流动力学、冠脉循环及心肌氧代谢的影响。
方法
本研究中，用PAMD或生理盐水（NS）处理麻醉犬，测量左室收缩压（LVSP）、左室舒张末压（LVEDP）及±dp/dtmax、冠状动脉血流量和心肌能量代谢的变化。
结果
在麻醉犬中，与预处理状态相比，3.5和7.0mg·kg-1的PAMD可使左室收缩压（LVSP）、±dp/dtmax、心率、氧利用率、冠脉和总外周阻力降低。发现其可增加心肌氧和冠脉血流量。左室舒张末压（LVEDP）无显著变化。
结论
PAMD可改善血流动力学、冠脉循环及心肌代谢。
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