Artiukhov V G, Putintseva O V, Dmitriev E V
Faculty of Biology and Soil Science, Voronezh State University, Voronezh, 394006 Russia.
Radiats Biol Radioecol. 2003 Jan-Feb;43(1):82-6.
The influence of ultraviolet (UV) radiation on structural and functional condition of membranes T- and B-lymphocytes of human blood is investigated. It is shown, that intergral flow of UV-light (240-390 nm) in doses 151-1359 J/m2 leads to the increase of the expression of some HLA-antigen (DR1, DR2, DR5, DR7) and Fc-receptors on membranes of B-lymphocytes. The level of HLA-antigen was increased by 20-500% from the initial state after exposure to different doses. The growth of the expression of Fc-receprots was registered in 80% of the donors in the range from 20 up to 540%. The minimum dose of UV-light (151 J/m2) caused the maximum effect. The reduction of the level of Fc-receptors by 10-90% relatively to the native condition was registered for T-cells in 80% of the donors. Groups of the donors were revealed, T-lymphocytes of which differed by the sensitivity to UV-radiation. The effect of "strengthening--weakening", resulting to the reduction of the initially high parameters and to increase in the initially low ones was found.
研究了紫外线（UV）辐射对人血T淋巴细胞和B淋巴细胞细胞膜结构和功能状态的影响。结果表明，剂量为151 - 1359 J/m²的紫外线（240 - 390 nm）的积分流量会导致B淋巴细胞细胞膜上某些HLA抗原（DR1、DR2、DR5、DR7）和Fc受体的表达增加。暴露于不同剂量后，HLA抗原水平相对于初始状态增加了20% - 500%。80%的供体中Fc受体表达增长范围为20%至540%。最小剂量的紫外线（151 J/m²）产生了最大效果。80%的供体中，T细胞的Fc受体水平相对于天然状态降低了10% - 90%。发现了不同供体组，其T淋巴细胞对紫外线辐射的敏感性不同。发现了“增强 - 减弱”效应，即导致初始高参数降低和初始低参数增加。
