Lu Yi-yu, Yan Ju-ying, Zhou Min, Jiang Xiao-lu
Institute of Virology, Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Jan;24(1):15-8.
To compare the characterization of hemagglutination and the sequence of HA1 region of the influenza A (H3N2) virus in Zhejiang province and Japan in recent years.
Hemagglutinin antigenic analysis of influenza A (H3N2) viruses which were isolated in Zhejiang province was carried out and to compare their characterization of hemagglutination and the sequence of amino acids in HA1 region with the virus strains from Japan during the same period.
The antigenicity and the amino acid sequence in HA1 region of the virus strains prevalent in Zhejiang in recent years have changed to some extent. Most of the virus strains were lack of hemagglutination reaction to chicken red blood cell and became "O" phase virus strains. The amino acid sequence of HA1 region of the virus strains exhibited only 94.82% of its homology with that of A/Wuhan/359/95 strain. The virus strains of Japan in the same period showed similar characteristics.
HA1 gene variation of influenza A (H3N2) viruses was the main cause leading to the spread of influenza in the last years.
比较近年来浙江省与日本甲型（H3N2）流感病毒的血凝特性及HA1区序列。
对浙江省分离的甲型（H3N2）流感病毒进行血凝素抗原性分析，并将其血凝特性及HA1区氨基酸序列与同期日本的病毒株进行比较。
近年来浙江省流行的病毒株抗原性及HA1区氨基酸序列有一定变化。多数病毒株对鸡红细胞缺乏血凝反应，成为“O”相病毒株。病毒株HA1区氨基酸序列与A/武汉/359/95株仅表现出94.82%的同源性。同期日本的病毒株表现出相似特征。
甲型（H3N2）流感病毒HA1基因变异是近年流感传播的主要原因。
