[2004 - 2008年中国甲型流感病毒抗原性及HA1基因特征研究]

[Study on the antigenicity and HA1 gene characteristics of influenza A viruses during 2004-2008 year in China].

作者信息

Zhang Ye, Zhao Xiang, Huang Wei-juan, Guo Jun-feng, Wei He-jiang, Cheng Yan-hui, Li Xin-wan, Li Xi-yan, Guo Yuan-ji, Shu Yue-long

机构信息

State Key Laboratory for Viral Genetic Engineering, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing.

出版信息

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Dec;23(6):405-8.

PMID:20718339

Abstract

OBJECTIVE

To under stand influenza A viruses epidemic, antigenicity and genetic characteristics variation between the vaccine and Circulation strains during 2004-2008 year in China.

METHODS

The influenza A viruses (H1N1, H3N2) isolated from 2004-2008 year were under took antigenic and sequence analysis. Influenza A virus antigenicity and genetic characteristics were analyzed thought amino acid variation compassion of HA1 protein of influenza A virus isolates.

RESULTS

The antigenicity of influenza H1N1 subtype viruses isolated from 2004 to 2007 is very similar with vaccine strain A/New Caledonia/20/1999 (HIN1)-like virus. The influenza H1N1 viruses circulated in 2008 year had similar antigenic characteristics with A/Brisben/59/2007 (H1N1) which is component of influenza vaccines for northern hemisphere 2008-2009 year. The influenza H3N2 subtype viruses of 2004-2005 year had antigenic variation comparatively with vaccine strain A/Fujian/411/12002 (H3N2), The antigenicity of 2006-2007 H3N2 viruses and 2008 year's is A/Wiscansin/67/2006(H3N2) and A/ Brisben/10/2006(H3N2) respectively.

CONCLUSION

There is change of influenza A viruses (H1N1, H3N2) antigenic and genetic characteristics during 2004-2008 in China.

摘要

目的

了解2004 - 2008年中国甲型流感病毒的流行情况、抗原性以及疫苗株与流行株之间的基因特征变异。

方法

对2004 - 2008年分离的甲型流感病毒（H1N1、H3N2）进行抗原性和序列分析。通过对甲型流感病毒分离株HA1蛋白氨基酸变异比较分析甲型流感病毒的抗原性和基因特征。

结果

2004年至2007年分离的甲型H1N1亚型病毒的抗原性与疫苗株A/新喀里多尼亚/20/1999（H1N1）样病毒非常相似。2008年流行的甲型H1N1病毒具有与A/布里斯班/59/2007（H1N1）相似的抗原特征，A/布里斯班/59/2007（H1N1）是2008 - 2009年北半球流感疫苗的一个组分。2004 - 2005年的甲型H3N2亚型病毒与疫苗株A/福建/411/2002（H3N2）相比有抗原性变异。2006 - 2007年H3N2病毒和2008年病毒的抗原性分别为A/威斯康星/67/2006（H3N2）和A/布里斯班/10/2006（H3N2）。