Boyne Michael S, Thame Minerva, Bennett Franklyn I, Osmond Clive, Miell John P, Forrester Terrence E
Tropical Metabolism Research Unit, Tropical Medicine Research Institute, The University of the West Indies, Mona, Kingston 7, Jamaica.
J Clin Endocrinol Metab. 2003 Apr;88(4):1687-91. doi: 10.1210/jc.2002-020633.
Fetal IGF-I is a determinant of birth weight, but whether maternal IGF-I plays a significant role is controversial. We sought to examine the relationships among maternal IGF-I, IGF-binding protein (IGFBP)-1, and IGFBP-2, with maternal and newborn anthropometry, in a cohort of 325 nondiabetic pregnant women of African origin. Blood was collected for IGF-I, IGFBP-1, and IGFBP-2 at 9, 25, and 35 wk gestation and in cord blood at delivery. In the second and third trimesters, maternal IGF-I was significantly correlated (P < 0.005) with maternal body mass index and triceps skinfold thickness. Maternal IGFBP-1 and -2 had an inverse correlation (P < 0.0001), with maternal anthropometry. Maternal IGF-I at 35 wk, and fetal IGF-I by cord blood were significantly correlated with birth weight (P = 0.001 and 0.048, respectively). IGFBP-1 in the third trimester and cord blood were negatively correlated with birth weight (P = 0.012 and 0.002). In multiple regression analyses, maternal IGF-I at 35 wk, fetal IGF-I, maternal weight at the first antenatal visit, gender, and gestational age were significant independent factors in the determination of birth weight. In conclusion, maternal IGF-I levels, especially during late pregnancy, positively influence birth weight.
胎儿胰岛素样生长因子-I（IGF-I）是出生体重的一个决定因素，但母体IGF-I是否起重要作用仍存在争议。我们试图在325名非洲裔非糖尿病孕妇队列中，研究母体IGF-I、IGF结合蛋白（IGFBP）-1和IGFBP-2与母体及新生儿人体测量学指标之间的关系。在妊娠9周、25周和35周时采集血液检测IGF-I、IGFBP-1和IGFBP-2，并在分娩时采集脐血。在妊娠中期和晚期，母体IGF-I与母体体重指数和肱三头肌皮褶厚度显著相关（P<0.005）。母体IGFBP-1和-2与母体人体测量学指标呈负相关（P<0.0001）。妊娠35周时的母体IGF-I和脐血中的胎儿IGF-I与出生体重显著相关（分别为P=0.001和0.048）。妊娠晚期和脐血中的IGFBP-1与出生体重呈负相关（P=0.012和0.002）。在多元回归分析中，妊娠35周时的母体IGF-I、胎儿IGF-I、首次产前检查时的母体体重、性别和孕周是出生体重决定的重要独立因素。总之，母体IGF-I水平，尤其是在妊娠晚期，对出生体重有积极影响。
