Izbicki Tadeusz, Mazur Joanna, Izbicka Elzbieta
Departments of Surgical Oncology and Epidemiology, National Research Institute of Mother and Child, Kasprzaka 17A Street, 01-211 Warsaw, Poland.
Anticancer Res. 2003 Jan-Feb;23(1B):755-60.
Neuroblastoma is a complex and therapeutically challenging malignant disease in children. This tumor of the sympathetic nervous system, derived from pathologically maturing neural crest progenitor cells, is unique among pediatric cancers because of spontaneous regressions and catecholamine excretion. Causal treatment of cancer requires a comprehensive understanding of cancer etiology and pathogenesis. Yet, since no causative factors have been identified to date for neuroblastoma, the epidemiological and etiology data summarized in this report might shed more light on carcinogenesis and the outcomes of this pediatric cancer.
神经母细胞瘤是一种复杂且治疗具有挑战性的儿童恶性疾病。这种起源于病理成熟神经嵴祖细胞的交感神经系统肿瘤，因可自发消退和儿茶酚胺排泄，在儿童癌症中独具特色。癌症的病因治疗需要对癌症的病因和发病机制有全面的了解。然而，由于迄今为止尚未确定神经母细胞瘤的致病因素，本报告中总结的流行病学和病因学数据可能会为这种儿童癌症的致癌机制和预后提供更多线索。
