Geerts Dirk, Revet Ingrid, Jorritsma Gerda, Schilderink Nathalie, Versteeg Rogier
Department of Human Genetics M1-131, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Cancer Lett. 2005 Oct 18;228(1-2):43-50. doi: 10.1016/j.canlet.2005.01.047.
The common pediatric tumor neuroblastoma originates from primitive neural crest-derived precursor cells of the peripheral nervous system. Neuroblastoma especially affects very young children, and can already be present at birth. Its early onset and cellular origin predict the involvement of developmental control genes in neuroblastoma etiology. These genes are indispensable for the tight regulation of normal embryonic development but as a consequence cause cancer and congenital diseases upon mutation or aberrant expression. To date however, the connotation of these genes in neuroblastoma pathogenesis is scant. This review recapitulates data on the MEIS homeobox control genes in cancer and focuses on neuroblastoma.
常见的儿科肿瘤神经母细胞瘤起源于外周神经系统中原始神经嵴衍生的前体细胞。神经母细胞瘤尤其影响幼儿，甚至在出生时就可能已经存在。其早期发病和细胞起源预示着发育控制基因参与神经母细胞瘤的病因学。这些基因对于正常胚胎发育的严格调控是不可或缺的，但因此在发生突变或异常表达时会导致癌症和先天性疾病。然而，迄今为止，这些基因在神经母细胞瘤发病机制中的内涵尚少。本综述概述了癌症中MEIS同源框控制基因的数据，并重点关注神经母细胞瘤。
