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高压氧作为恶性外耳道炎的辅助治疗方法。

Hyperbaric oxygen as an adjuvant treatment for malignant otitis externa.

作者信息

Phillips John S, Jones Stephen E M

机构信息

Department of Otolaryngology, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK.

出版信息

Cochrane Database Syst Rev. 2013 May 31;2013(5):CD004617. doi: 10.1002/14651858.CD004617.pub3.

Abstract

BACKGROUND

Malignant, or necrotising, otitis externa is a potentially fatal infection of the external ear canal and surrounding soft tissue and bone. It may be complicated by involvement of cranial nerves, principally the facial nerves and the contents of the jugular foramen. It is an uncommon condition mainly found in the elderly or in diabetics.

OBJECTIVES

To assess the effectiveness of adjunctive hyperbaric oxygen treatment for malignant otitis externa.

SEARCH METHODS

We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL); PubMed; EMBASE; CINAHL; Web of Science; ICTRP and additional sources for published and unpublished trials. The date of the most recent search was 4 April 2013.

SELECTION CRITERIA

Randomised controlled trials, involving adults, undergoing hyperbaric oxygen therapy in malignant otitis externa.

DATA COLLECTION AND ANALYSIS

No identified articles described randomised controlled trials of hyperbaric oxygen therapy in the treatment of malignant otitis externa.

MAIN RESULTS

Due to the lack of data we could present no results.

AUTHORS' CONCLUSIONS: No clear evidence exists to demonstrate the efficacy of hyperbaric oxygen therapy when compared to treatment with antibiotics and/or surgery. We found no data to compare rates of complication between the different treatment modalities. Further research is required.

摘要

背景

恶性外耳道炎,或称坏死性外耳道炎,是外耳道及周围软组织和骨质的一种潜在致命性感染。它可能因累及颅神经(主要是面神经和颈静脉孔内容物)而出现并发症。这是一种不常见的病症,主要见于老年人或糖尿病患者。

目的

评估辅助高压氧治疗恶性外耳道炎的有效性。

检索方法

我们检索了Cochrane耳、鼻、喉疾病组试验注册库;Cochrane对照试验中央注册库(CENTRAL);PubMed;EMBASE;CINAHL;科学引文索引;国际临床试验注册平台以及其他已发表和未发表试验的来源。最近一次检索日期为2013年4月4日。

选择标准

涉及成人的、采用高压氧治疗恶性外耳道炎的随机对照试验。

数据收集与分析

未检索到描述高压氧治疗恶性外耳道炎随机对照试验的文章。

主要结果

由于缺乏数据,我们无法给出结果。

作者结论

与抗生素和/或手术治疗相比,尚无明确证据证明高压氧治疗的疗效。我们未找到比较不同治疗方式并发症发生率的数据。需要进一步研究。

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本文引用的文献

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Malignant otitis externa with optic neuritis.恶性外耳道炎伴视神经炎。
J Laryngol Otol. 1998 Mar;112(3):274-7. doi: 10.1017/s0022215100158335.
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Malignant otitis externa.恶性外耳道炎
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Complications of the treatment of malignant external otitis.恶性外耳道炎治疗的并发症
Laryngoscope. 1983 Mar;93(3):279-81. doi: 10.1288/00005537-198303000-00005.
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Malignant external otitis: a dangerous misnomer?恶性外耳道炎:一个危险的误称?
Otolaryngol Head Neck Surg. 1982 Mar-Apr;90(2):266-9. doi: 10.1177/019459988209000223.

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