慢性阻塞性肺疾病患者的血浆食欲素-A水平与身体组成
Plasma orexin-A levels and body composition in COPD.
作者信息
Matsumura Takeshi, Nakayama Mika, Satoh Hiroaki, Naito Asuka, Kamahara Kazuyuki, Sekizawa Kiyohisa
机构信息
Department of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-city, Ibaraki, Japan.
出版信息
Chest. 2003 Apr;123(4):1060-5. doi: 10.1378/chest.123.4.1060.
STUDY OBJECTIVE
To study the role of orexins in regulating body composition in patients with COPD.
DESIGN
Prospective study.
PATIENTS AND MEASUREMENTS
We measured the plasma concentration of orexin-A in 20 patients with COPD and compared the results to those obtained from 10 age-matched control subjects. Patients with COPD were classified into two groups based on their body mass index (BMI): a normal weight (NW) group (BMI > 20) and an underweight (UW) group (BMI < 20).
RESULTS
The plasma orexin-A level was significantly lower in patients with COPD than in control subjects. In patients with COPD, the level was significantly lower in the UW group than in the NW group. Plasma orexin-A levels significantly correlated with BMI and fat mass values, but there was no significant relationship between plasma orexin-A levels and the fat-free mass of patients with COPD.
CONCLUSION
These results suggest that orexin-A levels are altered with weight loss and changes in body composition in patients with COPD.
研究目的
探讨食欲素在慢性阻塞性肺疾病（COPD）患者身体成分调节中的作用。
设计
前瞻性研究。
患者与测量
我们测量了20例COPD患者的血浆食欲素-A浓度，并将结果与10例年龄匹配的对照受试者的结果进行比较。COPD患者根据体重指数（BMI）分为两组：正常体重（NW）组（BMI>20）和体重过轻（UW）组（BMI<20）。
结果
COPD患者的血浆食欲素-A水平显著低于对照受试者。在COPD患者中，UW组的水平显著低于NW组。血浆食欲素-A水平与BMI和脂肪量值显著相关，但COPD患者的血浆食欲素-A水平与去脂体重之间无显著关系。
结论
这些结果表明，COPD患者的食欲素-A水平随体重减轻和身体成分变化而改变。
Zotero 插件