Luo Feng-Ming, Liu Xiao-Jing, Li Shuang-Qing, Wang Zeng-Li, Liu Chun-Tao, Yuan Yi-Ming
West China Hospital of Sichuan University, Chengdu, China.
Nutrition. 2005 Jul-Aug;21(7-8):793-8. doi: 10.1016/j.nut.2004.11.015.
Unexplained weight loss is common in patients with chronic obstructive pulmonary disease (COPD). Because ghrelin plays an important role in energy homeostasis, this study investigated the plasma level of ghrelin in COPD.
Plasma ghrelin levels and levels of leptin, tumor necrosis factor-alpha, and C-reactive protein were measured in 29 patients with COPD and 17 healthy controls. Body composition was assessed with bioelectrical impedance analysis.
Body mass index and percentage of body fat were lower in patients who had COPD than in healthy controls. Plasma ghrelin and leptin concentrations were significantly lower in patients who had COPD than in healthy controls (ghrelin: 0.25+/-0.22 ng/mL versus 0.43+/-0.24 ng/mL, P=0.013; leptin: 1.77+/-0.70 ng/mL versus 2.85+/-0.96 ng/mL, P=0.000). In contrast, tumor necrosis factor-alpha and C-reactive protein were significantly higher in those with COPD than in controls. Plasma ghrelin (log transformed) was positively correlated with body mass index and percentage of body fat in patients with COPD but negatively correlated in control subjects. Plasma ghrelin was negatively correlated with tumor necrosis factor-alpha and C-reactive protein in COPD.
Plasma ghrelin level was decreased in COPD and this is different from other weight-loss diseases. These data suggest that decreased ghrelin and other factors may contribute to alterations in metabolic status during inflammatory stress in this disease.
不明原因体重减轻在慢性阻塞性肺疾病（COPD）患者中很常见。由于胃饥饿素在能量平衡中起重要作用，本研究调查了COPD患者血浆胃饥饿素水平。
测量了29例COPD患者和17名健康对照者的血浆胃饥饿素水平以及瘦素、肿瘤坏死因子-α和C反应蛋白水平。采用生物电阻抗分析评估身体成分。
COPD患者的体重指数和体脂百分比低于健康对照者。COPD患者的血浆胃饥饿素和瘦素浓度显著低于健康对照者（胃饥饿素：0.25±0.22 ng/mL对0.43±0.24 ng/mL，P = 0.013；瘦素：1.77±0.70 ng/mL对2.85±0.96 ng/mL，P = 0.000）。相反，COPD患者的肿瘤坏死因子-α和C反应蛋白显著高于对照组。COPD患者血浆胃饥饿素（对数转换后）与体重指数和体脂百分比呈正相关，而在对照者中呈负相关。COPD患者血浆胃饥饿素与肿瘤坏死因子-α和C反应蛋白呈负相关。
COPD患者血浆胃饥饿素水平降低，这与其他体重减轻疾病不同。这些数据表明，胃饥饿素降低及其他因素可能导致该疾病炎症应激期间代谢状态的改变。
