Ang H H, Lee K L
School of Pharmaceutical Sciences, University Science Malaysia, Minden, 11800, Penang, Malaysia.
Fundam Clin Pharmacol. 2002 Dec;16(6):479-83. doi: 10.1046/j.1472-8206.2002.00106.x.
The effects of various fractions of Eurycoma longifolia Jack were studied on the orientation activities of the inbred, adult middle-aged Sprague-Dawley rats, 9 months old and retired breeders towards the receptive females (anogenital sniffing, licking, mounting), the environment (climbing, raring, exploration), themselves (nongenital grooming, genital grooming) and mobility (restricted, unrestricted) after treating these subjects twice daily for 10 days. Results showed that subjects treated with 800 mg/kg of E. longifolia Jack increased orientation activities towards the receptive females (anogenital sniffing, licking and mounting), increased genital grooming towards themselves and restricted movements to a particular area of the cage but decreased interest in the external environment (climbing, raring, exploration) as compared with the controls during the investigation period. In conclusion, this study gives further evidences that different fractions of E. longifolia Jack modified the orientation activities of the middle-aged male rats.
对9个月大的近交成年中年斯普拉格-道利大鼠（退休种鼠），每天两次、连续10天给予长叶刺蒺藜不同组分提取物处理后，研究其对处于发情期雌性大鼠（肛门生殖器嗅探、舔舐、爬跨）、环境（攀爬、竖尾、探索）、自身（非生殖器梳理、生殖器梳理）的定向行为以及活动能力（受限、不受限）的影响。结果显示，与对照组相比，在研究期间，给予800mg/kg长叶刺蒺藜提取物处理的大鼠对处于发情期雌性大鼠的定向行为（肛门生殖器嗅探、舔舐和爬跨）增加，对自身的生殖器梳理增加，且活动局限于笼子的特定区域，但对外部环境（攀爬、竖尾、探索）的兴趣降低。总之，本研究进一步证明长叶刺蒺藜不同组分可改变中年雄性大鼠的定向行为。
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