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长叶刺蒺藜与性经验丰富的雄性大鼠的定向活动

Eurycoma longifolia JACK and orientation activities in sexually experienced male rats.

作者信息

Ang H H, Sim M K

机构信息

School of Pharmaceutical Sciences, University of Science Malaysia, Penang.

出版信息

Biol Pharm Bull. 1998 Feb;21(2):153-5. doi: 10.1248/bpb.21.153.

Abstract

The effects of Eurycoma longifolia JACK were studied on the orientation activities of sexually experienced male rats towards receptive females (mounting, licking, anogenital sniffing), environment (exploration, raring, climbing), themselves (genital grooming, non-genital grooming) and mobility (unrestricted, restricted) after dosing them with 200, 400 and 800 mg/kg body weight twice daily for 10 d prior to the test. The results showed that E. longifolia JACK modified the orientation activities of the treated male rats in that they significantly displayed more frequent and vigorous mounting, licking and anogenital sniffing towards the receptive females, and it further intensified self orientation as indicated by the increased grooming of the genitals compared to the controls (p<0.05). In addition, rats treated with 800 mg/kg of methanol, water and butanol extracts of E. longifolia JACK continued to show confinement to a particular area of the cage (around the female), thus showing restriction in movement as compared to the controls (p<0.05). However, the treated males possessed a lack of interest in the external environment as indicated by a reduction in exploration, raring and climbing on the cage wall. Hence, the present study further supports the folk use of E. longifolia JACK as an aphrodisiac.

摘要

在测试前,每天两次给雄性大鼠按200、400和800毫克/千克体重的剂量灌胃长叶刺蒺藜(Eurycoma longifolia JACK),持续10天,研究其对有性经验的雄性大鼠针对处于发情期雌性大鼠的定向行为(爬跨、舔舐、肛门生殖器嗅探)、对环境的行为(探索、竖毛、攀爬)、对自身的行为(生殖器梳理、非生殖器梳理)以及活动能力(不受限制、受限制)的影响。结果表明,长叶刺蒺藜改变了受试雄性大鼠的定向行为,它们对处于发情期的雌性大鼠表现出更频繁、更剧烈的爬跨、舔舐和肛门生殖器嗅探,并且与对照组相比,其生殖器梳理增加,进一步强化了自我定向行为(p<0.05)。此外,用800毫克/千克长叶刺蒺藜的甲醇、水和丁醇提取物处理的大鼠继续表现出局限于笼子的特定区域(雌性大鼠周围),因此与对照组相比活动受到限制(p<0.05)。然而,受试雄性大鼠对外部环境缺乏兴趣,表现为探索、竖毛和攀爬笼壁的行为减少。因此,本研究进一步支持了长叶刺蒺藜作为壮阳药的民间用途。

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