Helbok R, Dent W, Nacher M, Treeprasertsuk S, Krudsood S, Wilairatana P, Silachamroon U, Looareesuwan S, Schmutzhard E
Department of Neurology, University of Innsbruck, Innsbruck, Austria.
Am J Trop Med Hyg. 2003 Mar;68(3):372-5.
The usual criteria for severe malaria are not always sufficient to identify patients who subsequently develop this disease. The multi-organ dysfunction score (MODS) was assessed in 22 patients with uncomplicated Plasmodium falciparum malaria to test its usefulness in discriminating different severity levels. The MODS on admission was highly correlated with the baseline concentration of tumor necrosis factor--alpha (r = 0.83, P < 0.001) and the duration of symptoms after admission (r = 0.54, P = 0.01). The MODS was also correlated with parasite count (r = 0.52, P = 0.014), parasite clearance time (r = 0.54, P = 0.009), and fever clearance time (r = 0.58, P = 0.005). The above correlations remained significant after controlling for the initial parasitemia (P = 0.03 and 0.005). The MODS is simple and easy to apply and needs a recording time of less than three minutes. Thus, this score might provide a quantitative approach for determining severity in Plasmodium falciparum malaria.
通常用于判定重症疟疾的标准并不总能识别出随后会发展为该病的患者。对22例非复杂性恶性疟原虫疟疾患者进行了多器官功能障碍评分（MODS），以测试其在区分不同严重程度方面的作用。入院时的MODS与肿瘤坏死因子-α的基线浓度高度相关（r = 0.83，P < 0.001）以及入院后症状持续时间相关（r = 0.54，P = 0.01）。MODS还与寄生虫计数（r = 0.52，P = 0.014）、寄生虫清除时间（r = 0.54，P = 0.009）以及发热清除时间（r = 0.58，P = 0.005）相关。在控制初始寄生虫血症后，上述相关性仍然显著（P = 0.03和0.005）。MODS简单易用，记录时间不到三分钟。因此，该评分可能为确定恶性疟原虫疟疾的严重程度提供一种定量方法。
