Jensen Charlotte D, Andersen Klaus E
Department of Dermatology, Odense University Hospital, University of Southern Denmark, Odense and National Allergy Research Centre, Gentofte, Denmark.
Environ Health. 2003 Mar 26;2:3. doi: 10.1186/1476-069x-2-3.
Metal-working fluids contain complex mixtures of chemicals and metal workers constitute a potential risk group for the development of allergic contact dermatitis.
Two metal workers developed allergic contact dermatitis on the hands and lower arms from exposure to a neat oil used in metal processing. Patch testing revealed that the relevant contact allergen was a cycloaliphatic epoxy resin, 1,2-cyclohexanedicarboxylic acid, bis(oxiranylmethyl) ester, added to the oil as a stabilizer. None of the patients had positive reactions to the bisphenol A-based epoxy resin in the standard series.
These cases emphasize that well-known contact allergens may show up from unexpected sources of exposure. Further, it can be a long-lasting, laborious process to detect an occupational contact allergen and cooperation from the patient and the manufacturer of the sensitizing product is essential.
金属加工液含有复杂的化学混合物,金属加工工人是发生过敏性接触性皮炎的潜在风险群体。
两名金属加工工人因接触金属加工中使用的纯油而在手部和前臂发生过敏性接触性皮炎。斑贴试验显示,相关接触性变应原是作为稳定剂添加到油中的一种脂环族环氧树脂,1,2-环己烷二甲酸双(环氧乙烷基甲基)酯。在标准系列中,两名患者对双酚A基环氧树脂均无阳性反应。
这些病例强调,知名的接触性变应原可能来自意想不到的接触源。此外,检测职业性接触性变应原可能是一个漫长而费力的过程,患者与致敏产品制造商的合作至关重要。