Simrén Magnus, Vos Rita, Janssens Jozef, Tack Jan
Dept. of Internal Medicine, Division of Gastroenterology, Univ. Hospital Gasthuisberg, University of Leuven, Belgium.
Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G309-15. doi: 10.1152/ajpgi.00242.2002. Epub 2003 Apr 9.
Duodenal acid has been suggested to be of importance for dyspeptic symptoms. We investigated the effects of acid on duodenal mechanosensitivity and antroduodenal motility in 10 healthy subjects before and during duodenal infusion of acid (0.1 N HCl) or water by using a combined barostat-manometry assembly. During acid infusion, increased sensitivity to balloon distension was seen, with reduced perception (P = 0.04) and discomfort thresholds (P = 0.06) and higher intensity of discomfort (P = 0.02) compared with water. Higher balloon volumes were seen during acid infusion, indicating decreased tone (P = 0.05). Large volume waves were more prevalent during acid than water infusion (P = 0.009). The acid infusion suppressed antral contractions (P = 0.04) and increased the number of contractions in the proximal duodenum (P = 0.02) compared with before the infusion. In conclusion, duodenal acid enhances mechanical sensitivity in the duodenum, affects gastroduodenal motor function, and might be of importance for dyspeptic symptoms.
十二指肠酸被认为对消化不良症状很重要。我们通过使用联合恒压器-测压装置，在10名健康受试者十二指肠输注酸（0.1N HCl）或水之前和期间，研究了酸对十二指肠机械敏感性和胃十二指肠运动的影响。在输注酸期间，观察到对球囊扩张的敏感性增加，与输注水相比，感觉阈值降低（P = 0.04）和不适阈值降低（P = 0.06），不适强度更高（P = 0.02）。在输注酸期间观察到球囊容积更大，表明张力降低（P = 0.05）。与输注水相比，输注酸期间大容积波更普遍（P = 0.009）。与输注前相比，输注酸抑制了胃窦收缩（P = 0.04），并增加了十二指肠近端的收缩次数（P = 0.02）。总之，十二指肠酸增强了十二指肠的机械敏感性，影响胃十二指肠运动功能，可能对消化不良症状很重要。
