用于药物的手性中间体的酶促合成。

Enzymatic synthesis of chiral intermediates for pharmaceuticals.

作者信息

Patel Ramesh, Hanson Ronald, Goswami Animesh, Nanduri Venkata, Banerjee Amit, Donovan Mary-Jo, Goldberg Steven, Johnston Robert, Brzozowski David, Tully Thomas, Howell Jeffrey, Cazzulino Dana, Ko Rapheal

机构信息

Process Research and Development, Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey, 08903, USA.

出版信息

J Ind Microbiol Biotechnol. 2003 May;30(5):252-9. doi: 10.1007/s10295-003-0032-6. Epub 2003 Mar 25.

DOI:10.1007/s10295-003-0032-6

PMID:12687489

Abstract

There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand by pharmaceutical industries for the preparation bulk drug substances. In this review article, microbial/enzymatic processes for the synthesis of chiral intermediates for antihypertensive drugs, melatonin receptor agonists, and beta3-receptor receptor agonists are described.

摘要

人们越来越意识到微生物和酶在以高化学选择性、区域选择性和对映选择性方式转化合成化学品方面的巨大潜力。制药行业对制备原料药的手性中间体有很高的需求。在这篇综述文章中，描述了用于合成抗高血压药物、褪黑素受体激动剂和β3受体激动剂的手性中间体的微生物/酶促过程。