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用于药物的手性中间体的酶促合成。

Enzymatic synthesis of chiral intermediates for pharmaceuticals.

作者信息

Patel Ramesh, Hanson Ronald, Goswami Animesh, Nanduri Venkata, Banerjee Amit, Donovan Mary-Jo, Goldberg Steven, Johnston Robert, Brzozowski David, Tully Thomas, Howell Jeffrey, Cazzulino Dana, Ko Rapheal

机构信息

Process Research and Development, Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey, 08903, USA.

出版信息

J Ind Microbiol Biotechnol. 2003 May;30(5):252-9. doi: 10.1007/s10295-003-0032-6. Epub 2003 Mar 25.

DOI:10.1007/s10295-003-0032-6
PMID:12687489
Abstract

There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand by pharmaceutical industries for the preparation bulk drug substances. In this review article, microbial/enzymatic processes for the synthesis of chiral intermediates for antihypertensive drugs, melatonin receptor agonists, and beta3-receptor receptor agonists are described.

摘要

人们越来越意识到微生物和酶在以高化学选择性、区域选择性和对映选择性方式转化合成化学品方面的巨大潜力。制药行业对制备原料药的手性中间体有很高的需求。在这篇综述文章中，描述了用于合成抗高血压药物、褪黑素受体激动剂和β3受体激动剂的手性中间体的微生物/酶促过程。

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Enzymatic synthesis of chiral intermediates for pharmaceuticals.用于药物的手性中间体的酶促合成。
J Ind Microbiol Biotechnol. 2003 May;30(5):252-9. doi: 10.1007/s10295-003-0032-6. Epub 2003 Mar 25.
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Biocatalytic synthesis of intermediates for the synthesis of chiral drug substances.用于合成手性药物中间体的生物催化合成。
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Microbial/enzymatic synthesis of chiral pharmaceutical intermediates.手性药物中间体的微生物/酶促合成
Curr Opin Drug Discov Devel. 2003 Nov;6(6):902-20.
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Microbial/enzymatic synthesis of chiral drug intermediates.手性药物中间体的微生物/酶促合成
Adv Appl Microbiol. 2000;47:33-78. doi: 10.1016/s0065-2164(00)47001-2.
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Biocatalysis: synthesis of chiral intermediates for drugs.生物催化：药物手性中间体的合成
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Chemo-enzymatic synthesis of pharmaceutical intermediates.药物中间体的化学-酶合成。
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Design and synthesis of melatonin receptors agonists and antagonists.褪黑素受体激动剂和拮抗剂的设计与合成。
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本文引用的文献

1
Recent progress in enzymatic resolution and desymmetrization of pharmaceuticals and their intermediates.药物及其中间体的酶促拆分和去对称化研究的最新进展。
Curr Opin Drug Discov Devel. 2000 Nov;3(6):764-82.
2
Enzymatic synthesis of chiral intermediates for Omapatrilat, an antihypertensive drug.用于抗高血压药物奥美帕替的手性中间体的酶促合成。
Biomol Eng. 2001 Jun;17(6):167-82. doi: 10.1016/s1389-0344(01)00068-5.
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Industrial biocatalysis.工业生物催化
Curr Opin Chem Biol. 2001 Apr;5(2):130-6. doi: 10.1016/s1367-5931(00)00181-2.
4
Dehydrogenases and transaminases in asymmetric synthesis.不对称合成中的脱氢酶和转氨酶。
Curr Opin Chem Biol. 2001 Apr;5(2):120-9. doi: 10.1016/s1367-5931(00)00180-0.
5
Biocatalytic preparation of a chiral synthon for a vasopeptidase inhibitor: enzymatic conversion of N(2)-.用于血管肽酶抑制剂的手性合成子的生物催化制备：N(2)-的酶促转化
Enzyme Microb Technol. 2000 Sep 1;27(6):376-389. doi: 10.1016/s0141-0229(00)00233-7.
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Biocatalysis for pharmaceuticals--status and prospects for a key technology.
Metab Eng. 2000 Jan;2(1):42-8. doi: 10.1006/mben.1999.0138.
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Synthesis of allysine ethylene acetal using phenylalanine dehydrogenase from Thermoactinomyces intermedius.利用中间嗜热放线菌的苯丙氨酸脱氢酶合成烯赖氨酸乙缩醛。
Enzyme Microb Technol. 2000 Mar 1;26(5-6):348-358. doi: 10.1016/s0141-0229(99)00175-1.
8
Enzymatic synthesis of L-6-hydroxynorleucine.L-6-羟基正亮氨酸的酶促合成
Bioorg Med Chem. 1999 Oct;7(10):2247-52. doi: 10.1016/s0968-0896(99)00158-3.
9
Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.
J Med Chem. 1997 May 23;40(11):1570-7. doi: 10.1021/jm970041e.
10
Chemical synthesis of allysine ethylene acetal and conversion in situ into 1-piperideine-6-carboxylic acid: key intermediate of the alpha-aminoadipic acid for beta-lactam antibiotics biosynthesis.烯赖氨酸乙撑缩醛的化学合成及原位转化为1-哌啶-6-羧酸：β-内酰胺抗生素生物合成中α-氨基己二酸的关键中间体
Bioorg Med Chem. 1995 Sep;3(9):1237-40. doi: 10.1016/0968-0896(95)00110-3.