药物及其中间体的酶促拆分和去对称化研究的最新进展。

Recent progress in enzymatic resolution and desymmetrization of pharmaceuticals and their intermediates.

作者信息

Pesti J A, Dicosimo R

机构信息

DuPont Pharmaceutical Company, Chemical Process Research & Development, DuPont Experimental Station, E336/147 Wilmington, DE 19880-0336, USA.

出版信息

Curr Opin Drug Discov Devel. 2000 Nov;3(6):764-82.

PMID:19649905

Abstract

The literature is surveyed from mid-1998 through to August 2000 for examples of the resolution or desymmetrization of existing/potential pharmaceutical entities and pharmaceutical intermediates, and of chiral building blocks for pharmaceutical manufacture. Examples of commercial interest are included with new developments in the art of resolution.

摘要

对1998年年中至2000年8月期间的文献进行了调研，以查找现有/潜在药物实体和药物中间体以及药物制造用手性砌块的拆分或去对称化实例。具有商业价值的实例与拆分技术的新进展一同列出。