Mohr S J, Chirigos M A, Smith G T, Fuhrman F S
Cancer Res. 1976 Jun;36(6):2035-9.
Pyran copolymer (NSC 46015) was found to potentiate strongly the immune response of C57BL/6J X DBA/2 F1 mice to 10(4) live L1210 tumor cells following suboptimal vaccination with 10(7) radiation-inactivated L1210 cells. Optimal immunity to challenge was produced by concomitant i.p administration of pyran and L1210 vaccine, and activity was dependent upon both pyran and vaccine dosages. In addition, this immunopotentiation seemed to be related to the intrinsic viscosity of different pyran preparations tested, although all the pyran compounds had significant activity. Furthermore, the increased immunity of subsequent live tumor challenge appeared to be specific for the vaccinating cell type.
发现吡喃共聚物（NSC 46015）在用10⁷经辐射灭活的L1210细胞进行次优剂量接种后，能强烈增强C57BL/6J×DBA/2 F1小鼠对10⁴个活L1210肿瘤细胞的免疫反应。通过腹腔内同时给予吡喃和L1210疫苗可产生对攻击的最佳免疫，且活性取决于吡喃和疫苗的剂量。此外，这种免疫增强似乎与所测试的不同吡喃制剂的特性黏度有关，尽管所有吡喃化合物都有显著活性。此外，后续活肿瘤攻击时免疫力的增强似乎对接种细胞类型具有特异性。
