Coltart Don M, Danishefsky Samuel J
The Laboratory for Bioorganic Chemistry, The Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
Org Lett. 2003 Apr 17;5(8):1289-92. doi: 10.1021/ol034213f.
[reaction: see text] An efficient and highly stereocontrolled approach to the 8,10-dimethyl anti-syn-anti-perhydrophenanthrene carbon skeleton starting with the Wieland-Miescher ketone is described. The approach centers on a Diels-Alder-angular methylation-deoxygenation sequence.
[反应：见正文] 描述了一种从维兰德-米舍尔酮开始构建8,10-二甲基反-顺-反-全氢菲碳骨架的高效且高度立体控制的方法。该方法以狄尔斯-阿尔德反应-角甲基化-脱氧序列为核心。
