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利用Illumina和PacBio技术对免疫抑制剂巴西他汀产生菌——诺卡氏菌属萜烯诺卡氏菌IFM 0406进行高质量基因组草图测序

High-Quality Draft Genome Sequence of the Actinobacterium Nocardia terpenica IFM 0406, Producer of the Immunosuppressant Brasilicardins, Using Illumina and PacBio Technologies.

作者信息

Buchmann Anina, Eitel Michael, Koch Pierre, Schwarz Paul N, Stegmann Evi, Wohlleben Wolfgang, Wolański Marcin, Krawiec Michał, Zakrzewska-Czerwińska Jolanta, Méndez Carmen, Botas Alma, Núñez Luz Elena, Morís Francisco, Cortés Jesus, Gross Harald

机构信息

Department of Pharmaceutical Biology, Institute of Pharmaceutical Sciences, University of Tübingen, Tübingen, Germany.

German Centre for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany.

出版信息

Genome Announc. 2016 Dec 15;4(6):e01391-16. doi: 10.1128/genomeA.01391-16.

DOI:10.1128/genomeA.01391-16
PMID:27979943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5159576/
Abstract

The bacterium Nocardia terpenica IFM 0406 is known as the producer of the immunosuppressant brasilicardin A. Here, we report the completely sequenced genome of strain IFM 0406, which facilitates the heterologous expression of the brasilicardin biosynthetic gene cluster but also unveils the intriguing biosynthetic capacity of the strain to produce secondary metabolites.

摘要

嗜松诺卡氏菌IFM 0406是免疫抑制剂巴西卡定A的产生菌。在此，我们报道了菌株IFM 0406的全基因组序列，该序列不仅有助于巴西卡定生物合成基因簇的异源表达，还揭示了该菌株产生次级代谢产物的有趣生物合成能力。

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