填补肌动蛋白细胞骨架重塑信号传导中的空白。

Filling gaps in signaling to actin cytoskeletal remodeling.

作者信息

Stossel Thomas P, Hartwig John H

机构信息

Hematology Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Dev Cell. 2003 Apr;4(4):444-5. doi: 10.1016/s1534-5807(03)00098-4.

DOI:10.1016/s1534-5807(03)00098-4

PMID:12689583

Abstract

A recent publication in the April 4 issue of Cell advances our understanding of stimulus response coupling leading to actin remodeling. It describes the identification of a novel membrane component Mig-2 that engages filamin A through a new intermediary, migfilin, to stimulate actin assembly and cell spreading on a substrate of extracellular matrix.

摘要

最近发表在4月4日《细胞》杂志上的一篇论文增进了我们对导致肌动蛋白重塑的刺激反应偶联的理解。它描述了一种新型膜成分Mig-2的鉴定，该成分通过一种新的中间体migfilin与细丝蛋白A结合，以刺激肌动蛋白组装和细胞在细胞外基质底物上的铺展。