Mullan H M, Munday P E
Department of Genitourinary Medicine, Watford General Hospital, Watford, Herts, UK.
Sex Transm Infect. 2003 Apr;79(2):129-33. doi: 10.1136/sti.79.2.129.
To determine the uptake of a type specific herpes simplex antibody test if it were offered as part of routine screening in a genitourinary medicine clinic in a district general hospital in the United Kingdom.
Stage 1. A series of 207 consecutive new attenders and 205 patients who had attended the clinic previously were given written information about the test and asked whether they would want to have the test if it were available. They were asked whether they would wish to discuss it further with a counsellor before making a decision. Stage 2. Another series of 434 consecutive patients were offered the test after reading an information leaflet detailing the advantages and disadvantages of being tested. They were also offered the opportunity to see a counsellor for further information.
In stage 1 of the study, 51% of men and 54% of women said they would want the test if it were available. 32% of men and 40% of women requested counselling. In stage 2, when the test was offered, 41% of men and 37% of women chose to have it, and 23% of men and 7% of women requested further information from the counsellor. 20 patients were herpes simplex virus type 2 (HSV-2) positive-four of whom would have been diagnosed on clinical grounds at the time of presentation. A further 12 men and 20 women excluded themselves from the study because they were known to have genital herpes. Therefore, type specific serology contributed 30% to total diagnoses in this population-16 out of a population of 52 would have remained undiagnosed without having had the test.
In this population, the uptake of the type specific herpes simplex antibody test was much less than expected and screening was of limited benefit in identifying large numbers of previously unrecognised HSV-2 positive patients.
确定在英国一家地区综合医院的泌尿生殖医学诊所,将特定类型的单纯疱疹抗体检测作为常规筛查的一部分时,其接受程度。
第一阶段。向连续就诊的207名新患者以及之前在该诊所就诊过的205名患者提供有关该检测的书面信息,并询问如果有该检测,他们是否愿意进行检测。还询问他们在做出决定之前是否希望与咨询师进一步讨论。第二阶段。在阅读了一份详细说明检测利弊的信息传单后,向另外连续的434名患者提供该检测。他们也有机会咨询咨询师以获取更多信息。
在研究的第一阶段,51%的男性和54%的女性表示如果有该检测,他们愿意进行检测。32%的男性和40%的女性要求咨询。在第二阶段,当提供该检测时,41%的男性和37%的女性选择进行检测,23%的男性和7%的女性要求咨询师提供更多信息。20名患者为单纯疱疹病毒2型(HSV - 2)阳性,其中4名在就诊时可根据临床症状诊断。另有12名男性和20名女性因已知患有生殖器疱疹而退出研究。因此,特定类型的血清学检测在该人群的总诊断中占30%,在52人的人群中,如果没有进行该检测,16人将仍未被诊断。
在该人群中,特定类型的单纯疱疹抗体检测的接受程度远低于预期,筛查在识别大量先前未被识别的HSV - 2阳性患者方面益处有限。