Strausberg Robert L, Schreiber Stuart L
Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Bethesda, MD 20892, USA.
Science. 2003 Apr 11;300(5617):294-5. doi: 10.1126/science.1083395.
The National Cancer Institute Initiative in Chemical Genetics is designed to encourage the development of small molecular probes. The probes are useful for activating or inactivating protein functions, thereby providing resources that help discern the functions of gene products in normal and disease cells, as well as in tissues. This initiative includes "ChemBank," a suite of informatics tools and databases aimed at promoting the development and use of chemical genetics by scientists worldwide. The information generated with such tools should provide a critical link from genomic discovery to drug development.
美国国立癌症研究所化学遗传学倡议旨在鼓励小分子探针的开发。这些探针可用于激活或使蛋白质功能失活，从而提供有助于识别正常细胞和疾病细胞以及组织中基因产物功能的资源。该倡议包括“化学文库”，这是一套信息学工具和数据库，旨在促进全球科学家对化学遗传学的开发和利用。利用这些工具生成的信息应提供从基因组发现到药物开发的关键联系。
