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用于合成具有生物动力学意义的1H-吡唑并[1,2-b]酞嗪-5,10-二酮衍生物的磁性可回收FeO纳米催化剂及其密度泛函理论研究

Magnetically recoverable FeO nanocatalyst for the synthesis of biodynamically significant 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives and its DFT study.

作者信息

Ansari Mohd Danish, Sagir Hozeyfa, Yadav Vijay B, Yadav Neetu, Verma Ankit, Shakya Sonam, Singh Manjit, Siddiqui I R

机构信息

Laboratory of Green Synthesis, Department of Chemistry, University of Allahabad, Allahabad, 211002, India.

Department of Chemistry, Paliwal P.G. College, Shikohabad, 205135, India.

出版信息

Mol Divers. 2023 Aug;27(4):1853-1866. doi: 10.1007/s11030-022-10532-3. Epub 2022 Oct 7.

Abstract

An environmentally sustainable and proficient method is reported for the synthesis of medicinally important pyrazolo[1,2-b] phthalazine dione derivatives by aqueous micellar medium catalysed by FeO NPs. Dialkyl acetylenedicarboxylate with isocyanides in the presence of phthalhydrazide is used as starting material. The main advantages of this protocol are the availability of starting materials, short reaction times, green solvents and practical simplicity.

摘要

报道了一种环境可持续且高效的方法,用于通过FeO纳米颗粒催化的水相胶束介质合成具有重要药用价值的吡唑并[1,2 - b]酞嗪二酮衍生物。以邻苯二甲酰肼存在下的二烷基乙炔二羧酸酯与异腈作为起始原料。该方法的主要优点是起始原料易得、反应时间短、使用绿色溶剂且操作简便。

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