Burgener F A, Fischer H W
Rofo. 1975 Feb;122(2):145-8. doi: 10.1055/s-0029-1230041.
56 intravenous cholangiograms were performed in eleven dogs with either advanced hepatic damage or complete common bile duct obstruction. If radiographic visualization of the biliary system did not occur within 8 hours after a 30 minute infusion with 0.6 ml/kg iodipamide 52%, the result could not be improved by just extending the infusion time to 2 and 6 hours. However, a slight improvement was obtained, when the iodipamide dose was increased up to 1.8 ml/kg. Nevertheless we do not recommend a massive increase of the dose in the icteric patient, because it is likely that the risk of toxic side effects increases with an increasing iodipamide dose.
对11只患有晚期肝损伤或完全性胆总管梗阻的犬进行了56次静脉胆管造影。如果在以0.6 ml/kg的52%碘番酸输注30分钟后8小时内未出现胆道系统的X线显影,则仅将输注时间延长至2小时和6小时并不能改善结果。然而,当碘番酸剂量增加至1.8 ml/kg时,情况稍有改善。尽管如此,我们不建议黄疸患者大量增加剂量,因为随着碘番酸剂量的增加,出现毒性副作用的风险可能会增加。