Burgener F A
AJR Am J Roentgenol. 1980 Apr;134(4):665-7. doi: 10.2214/ajr.134.4.665.
The time-density-retention concept was evaluated in chronic cholecystectomized bile fistula dogs with normal hepatic function, partial common bile duct obstruction, and hepatic parenchymal disease using either iodipamide or iodoxamate. In all investigated conditions, the maximum biliary iodine concentration was found earlier with iodoxamate than iodipamide but the difference was only significant in partial common bile duct obstruction. In this condition a significant delay in attaining the maximum biliary iodine concentration was found with iodipamide but not with iodoxamate. It is concluded that the time-density-retention concept represents a valid radiographic criterion for the diagnosis of partial common bile duct obstruction in cholecystectomized or cystic duct occluded subjects when iodipamide but not iodoxamate is used as contrast agent.
采用碘番酸或碘多啥胺，在肝功能正常、部分胆总管梗阻和肝实质疾病的慢性胆囊切除术后胆瘘犬中，对时间 - 密度 - 滞留概念进行了评估。在所有研究条件下，碘多啥胺比碘番酸更早发现最大胆管碘浓度，但差异仅在部分胆总管梗阻时显著。在这种情况下，碘番酸达到最大胆管碘浓度有显著延迟，而碘多啥胺则没有。得出的结论是，当使用碘番酸而非碘多啥胺作为造影剂时，时间 - 密度 - 滞留概念是胆囊切除或胆囊管闭塞患者诊断部分胆总管梗阻的有效影像学标准。
