Mokhtar M M, Abdel-Fattah M
Department of Human Genetics, Medical Research Institute, University of Alexandria, Alexandria, Egypt.
East Mediterr Health J. 2001 May;7(3):441-51.
We evaluated the hypothesis that the trisomy 21 genome interacts with environmental factors during early pregnancy to increase the risk for birth anomalies in Down syndrome infants in Alexandria, Egypt. A case-control study on 514 infants with confirmed Down syndrome was carried out from 1 July 1995 to 30 June 2000. Genetic, biological, environmental and reproductive factors were analysed. Multiple logistic regression analysis showed the following factors to be independently associated with increased risk of congenital heart diseases among Down syndrome patients: parental consanguinity, maternal parents' consanguinity, mother's antibiotics use in pregnancy, oral contraceptive use and diabetes in the mother. Fever in the mother during pregnancy was associated with increased risk of gastrointestinal anomalies.
在埃及亚历山大，21三体基因组在妊娠早期与环境因素相互作用，增加了唐氏综合征婴儿出生异常的风险。1995年7月1日至2000年6月30日，对514例确诊为唐氏综合征的婴儿进行了一项病例对照研究。分析了遗传、生物、环境和生殖因素。多因素逻辑回归分析显示，以下因素与唐氏综合征患者先天性心脏病风险增加独立相关：父母近亲结婚、母系父母近亲结婚、母亲孕期使用抗生素、口服避孕药以及母亲患糖尿病。母亲孕期发热与胃肠道异常风险增加有关。
