用于运动障碍的立体定向神经外科手术。

Stereotactic neurosurgery for movement disorders.

作者信息

Abosch Aviva, Lozano Andres

机构信息

Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA.

出版信息

Can J Neurol Sci. 2003 Mar;30 Suppl 1:S72-82. doi: 10.1017/s0317167100003279.

DOI:10.1017/s0317167100003279

PMID:12691480

Abstract

Stereotactic neurosurgery for the treatment of movement disorders focuses primarily on the treatment of Parkinson's disease (PD), essential tremor (ET), and dystonia. The surgical targets in use are the subthalamic nucleus (STN) and the globus pallidus internus (GPi) for PD, GPi for dystonia, and ventralis intermedius (Vim) nucleus of the thalamus for ET. Following target selection, procedures include the generation of lesions or the placement of deep brain stimulating electrodes in the selected target. Additionally, transplantation has been used in the treatment of PD. The indications, outcomes, and risks of the various procedures are reviewed.

摘要

用于治疗运动障碍的立体定向神经外科手术主要集中于帕金森病（PD）、特发性震颤（ET）和肌张力障碍的治疗。目前使用的手术靶点，对于帕金森病是丘脑底核（STN）和苍白球内侧部（GPi），对于肌张力障碍是GPi，对于特发性震颤是丘脑腹中间核（Vim）。选定靶点后，手术程序包括在选定靶点制造损伤或植入脑深部刺激电极。此外，移植已被用于帕金森病的治疗。本文对各种手术的适应症、疗效及风险进行了综述。