托吡酯对 Holmes 震颤有部分疗效：一例报告
Holmes Tremor Partially Responsive to Topiramate: A Case Report.
作者信息
Rojas Natalia González, Cesarini Martin, Etcheverry José Luis, Da Prat Gustavo, Viera Aramburu Tomás, Gatto Emilia Mabel
机构信息
Instituto Neurociencias Buenos Aires (INEBA), Departamento de Neurología - área de movimientos anormales, Buenos Aires, Argentina.
出版信息
Tremor Other Hyperkinet Mov (N Y). 2018 Jun 26;8:565. doi: 10.7916/D82C0FFN. eCollection 2018.
BACKGROUND
Holmes tremor is a rare symptomatic movement disorder, characterized by a combination of resting, postural, and intention tremor. It is usually caused by lesions in the brainstem, thalamus, and cerebellum. Despite pharmacological advances, its treatment remains a challenge; many medications have been used with various degrees of effectiveness. Stereotactic thalamotomy and deep brain stimulation in the ventralis intermedius nucleus have been effective surgical procedures in cases refractory to medical treatment.
CASE REPORT
Here we report a young woman with topiramate-responsive Holmes tremor secondary to a brainstem cavernoma.
DISCUSSION
Herein we report a Holmes tremor responsive to Topiramate.
背景
霍姆斯震颤是一种罕见的症状性运动障碍，其特征为静止性、姿势性和意向性震颤相结合。它通常由脑干、丘脑和小脑的病变引起。尽管药理学取得了进展，但其治疗仍然是一项挑战；许多药物已被使用，效果各不相同。立体定向丘脑切开术和腹中间核深部脑刺激在药物治疗难治的病例中是有效的外科手术。
病例报告
在此，我们报告一名年轻女性，患有继发于脑干海绵状血管瘤的托吡酯反应性霍姆斯震颤。
讨论
在此，我们报告了一例对托吡酯有反应的霍姆斯震颤。
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