Starr Philip A
University of California at San Francisco and San Francisco Veteran's Affairs Medical Center, Moffitt Hospital, San Francisco, CA 94143, USA.
Stereotact Funct Neurosurg. 2002;79(3-4):118-45. doi: 10.1159/000070828.
Deep brain stimulation (DBS) represents a major advance in the treatment of Parkinson's disease (PD). As more neurosurgeons enter this field, technical descriptions of implantation techniques are needed. Here we present our technical approach to subthalamic nucleus (STN) and globus pallidus internus (GPi) DBS implantation, based on 180 STN implants and 75 GPi implants. The essential steps in DBS implantation are magnetic resonance imaging (MRI)-guided stereotactic localization, confirmation of the motor territory of the target nucleus with microelectrode mapping, and intra-operative test stimulation to determine voltage thresholds for stimulation-induced adverse effects. Lead locations are documented by postoperative MRI in all cases.
脑深部电刺激术（DBS）是帕金森病（PD）治疗领域的一项重大进展。随着越来越多的神经外科医生进入该领域，需要对植入技术进行技术描述。在此，我们基于180例丘脑底核（STN）植入和75例苍白球内侧核（GPi）植入，介绍我们的STN和GPi DBS植入技术方法。DBS植入的基本步骤包括磁共振成像（MRI）引导的立体定向定位、通过微电极图谱确认目标核的运动区域，以及术中测试刺激以确定刺激诱发不良反应的电压阈值。所有病例均通过术后MRI记录电极位置。
